Dry　reforming　of　methane　(DRM)　is　an　attractive　route　to　utilize　CO2　as　a　chemical　feedstock　with　which　to　convert　CH4　into　valuable　syngas　and　simultaneously　mitigate　both　greenhouse　gases.　Ni-based　DRM　catalysts　are　promising　due　to　their　high　activity　and　low　cost,　but　suffer　from　poor　stability　due　to　coke　formation　which　has　hindered　their　commercialization.　Herein,　we　report　that　atomically　dispersed　Ni　single　atoms,　stabilized　by　interaction　with　Ce-doped　hydroxyapatite,　are　highly　active　and　coke-resistant　catalytic　sites　for　DRM.　Experimental　and　computational　studies　reveal　that　isolated　Ni　atoms　are　intrinsically　coke-resistant　due　to　their　unique　ability　to　only　activate　the　first　C-H　bond　in　CH4,　thus　avoiding　methane　deep　decomposition　into　carbon.　This　discovery　offers　new　opportunities　to　develop　large-scale　DRM　processes　using　earth　abundant　catalysts.