The　large-scale　shaking　table　model　test　is　adopted　for　study　the　behavior　associated　with　earthquake　shaking　of　the　prestressed　anchor　cable　retaining　the　slope.　Similarity　relation　is　derived　by　law　of　gravitivity　similitude　and　dimension　analysis　method.　Three　kinds　of　seismic　waves　are　inputted　to　study　the　dynamic　response　characters　of　prestressed　anchor　cable　while　the　amplitudes　of　input　seismic　waves　are　increased.　Axial　force　of　prestressed　anchor　cable　and　the　acceleration　and　displacement　time　history　are　monitored　to　study　the　loss　of　prestress　and　axial　force　of　prestressed　anchor　cable　subjected　to　earthquake　shaking.　Slope　stability　is　also　studied.　The　results　show　that　loss　of　axial　force　and　prestress　of　prestressed　anchor　cable　varies　with　the　change　of　input　seismic　wave.　The　maximum　value　of　prestressing　loss　is　15.7%　and　with　the　increment　of　the　peak　value　of　input　seismic　waves,　the　prestresssing　loss　increased　at　first　and　then　decreased　to　the　critical　value　while　prestressing　loss　is　no　longer　occurred.　It　is　proposed　that　the　applied　prestress　value　should　be　1.1　to　1.2　times　of　the　designed　value　of　the　prestress　during　seismic　design　of　prestessed　cable　anchor,　which　is　higher　than　the　value　under　static　conditions.