Differential expressions of miRNA in human mesenchymal stem cells derived from umbilical cord and bone marrow - 文章详情页

作者：

Zhang, Fang (Zhang, Fang.) | Chen, Xue-Bin (Chen, Xue-Bin.) | Sheng, Wang (Sheng, Wang.) (学者：盛望)

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EI Scopus PKU CSCD

摘要：

Expressions　of　miRNA　in　human　mesenchymal　stem　cells　derived　from　umbilical　cord　and　bone　marrow　were　detected　by　microarray.　Results　indicated　that　the　expressions　of　a　set　of　26　miRNA　were　different　in　UMSCs　and　BMSCs.　miR-29b,　miR-20a,　miR-31,　miR-20b　and　miR-106a　exhibited　higher　expressions　in　UMSCs,　and　fold　changes　were　higher　than　3.　However,　miR-138　demonstrated　lower　expression.　Based　on　this　study,　6　miRNAs　of　particular　interests　were　confirmed　by　real-time　PCR,　and　the　results　coincidented　with　those　of　mircoarray.　Target　genes　predictive　were　correlated　with　mRNA　transcript,　translation,　and　the　functions　of　cell　proliferation,　division,　and　signal　transduction.

关键词：

Stem cells Signal transduction Polymerase chain reaction Cell proliferation RNA Bone Cell culture Microarrays

作者机构：

[ 1 ] [Zhang, Fang]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
[ 2 ] [Chen, Xue-Bin]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
[ 3 ] [Sheng, Wang]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China

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