A　plate　heat　pipe　heat　exchanger　for　room　ventilation　was　designed.　The　advantages　of　the　heat　pipe　heat　exchanger　are　small　and　high　compactness.　In　this　paper,　the　effect　of　the　working　fluid　(R113,　R141b　and　their　mixture)　was　investigated　experimentally　for　the　performance　of　the　heat　pipe　heat　exchanger.　The　overall　experiments　were　carried　out　under　the　simulated　summer　condition,　the　vacuum　of　the　heat　pipe　heat　exchanger　was　set　at　1　×　10-3　Pa,　and　the　filling　ratio　(the　ratio　of　the　working　fluid　volume　in　the　heat　pipe　heat　exchanger　to　the　volume　of　the　heat　pipe　heat　exchanger)　was　1/3.　The　experimental　results　show　that　the　heat　pipe　heat　exchanger　could　gain　a　high　efficiency　of　heat　recovery.　The　effectiveness　of　heat　pipe　heat　exchanger　with　R141b　as　working　fluid　is　superior　to　other　working　fluid　over　the　whole　air　volume　range,　and　the　maximum　effectiveness　could　be　reached　58.2%.