Objective:　To　design　a　global　sliding　mode　control　algorithm　for　the　purpose　of　eliminating　the　chattering　effect　in　conventional　sliding　mode　control　algorithm　on　both　the　controller　and　controlled　plant　from　the　conventional　sliding　mode　control　algorithm　and　regulating　the　intra-aorta　pump　in　response　to　the　demand　of　blood　circulation　system　in　human.　Methods:　A　dynamic　disturbance　compensator　was　used　to　estimate　the　uncertainty　of　the　intra-aorta　pump　control　system.　Computer　simulations　and　in　vitro　experiments　were　also　conducted　to　verify　the　dynamic　characteristics　and　robustness　of　the　controller.　Results:　As　the　dynamic　disturbance　compensator　was　used　to　estimate　the　uncertainty　of　system,　the　chattering　effect　in　sliding　mode　control　algorithm　was　eliminated.　When　the　reference　flow　rate　was　set　at　5　L/min,　the　response　time　was　80　ms　without　any　overshot　and　static　error.　When　the　load　torque　of　the　controller　was　increased　to　0.4　N　·　m,　the　response　time　was　25　ms.　When　the　pulsatile　signal　was　input　as　the　reference　flow　rate,　the　dynamic　response　time　was　80　ms　with　the　maximum　error　of　flow　rate　being　0.03　L/min.　In　the　in　vitro　experiments,　as　the　feedback　frequency　of　flow　rate　signal　and　pump　speed　signal　were　lower　than　that　in　the　ideal　condition,　the　controller　performance　was　deteriorative　compared　with　computer　simulation.　The　experimental　results　demonstrated　that　when　the　reference　flow　rate　was　set　at　5　L/min,　the　response　time　was　0.26　s　with　the　error　of　flow　rate　being　0.1　L/min.　Conclusions:　The　controller　provided　in　this　paper　can　accurately　regulate　the　intra-aorta　pump　according　to　the　reference　flow　rate.　Furthermore,　it　has　a　strong　robustness　for　the　uncertainty　and　disturbance　of　the　control　system.　Due　to　the　use　of　dynamic　disturbance　compensator,　the　chattering　effect　of　the　algorithm　has　been　eliminated.