Metal-organic　frameworks　(MOFs)　nanoparticles　can　act　as　microporous　fillers　to　fabricate　high-performance　mixed　matrix　membranes　(MMMs)　for　solvent-resistant　nanofiltration　(SRNF)　application.　However,　a　high　content　of　MOFs　nanoparticles　mixed　in　a　polymeric　membrane　may　be　easily　to　form　MOFs　aggregates　and　MOFs/polymer　interface　defects,　attributing　to　the　decrease　in　membrane　selectivity.　In　this　study,　ZIF-8　core-shell　microspheres　were　synthesized　by　growing　microporous　ZIF-8　nanoparticles　on　the　outer　surface　of　macroporous　resin　microspheres　(RMs),　and　then　polyphenylsulfone　(PPSU)/ZIF-8@RMs　membranes　were　prepared　in　order　to　avoid　the　nonselective　PPSU/ZIF-8　defects　and　then　to　improve　SRNF　performance　of　PPSU　membranes.　The　effects　of　different　type　of　fillers　and　ZIF-8@RMs　content　in　PPSU　MMMs　were　evaluated　with　respect　to　structural　properties　and　SRNF　performance.　The　obtained　PPSU/ZIF-8@RMs　membranes　exhibited　higher　selectivity　compared　with　the　PPSU/ZIF-8　and　PPSU/RMs　membranes,　due　to　the　combination　of　the　affinity　of　ZIF-8　nanoparticles,　the　microporous　and　microsphere　structure　of　the　ZIF-8　shells　is　benefit　to　reduce　the　defects　between　ZIF-8@RMs　and　PPSU.　Compared　with　the　pure　PPSU　membrane　(with　a　rejection　of　53%　and　a　methanol　flux　of　35.2　kg　m(-2)　h(-1))　for　Methyl　red　(MR)　removal,　the　optimal　PPSU/ZIF-8@RMs　membrane　with　filler　content　of　5.0　wt%　significantly　exhibited　the　improved　rejection　of　88.8%　and　the　methanol　flux　slightly　decreased　to　33.0　kg　m(-2)　h(-1)　at　1.0　MPa.　Moreover,　the　PPSU/5.0　wt%　ZIF-8@RMs　membrane　remained　stable　in　12-h　SRNF　process,　and　the　MR　rejection　exceeding　86.2%　was　maintained.　This　method　provides　a　good　prospect　for　the　combination　of　polymeric　membranes　and　more　types　of　MOF　core-shell　composite　materials.