It　is　discussed　the　optimization　design　of　prestressed　cable-truss　structures　with　itsdesign　variables　including　cables＇　pretension　force,　cross　section　size　of　member　and　structural　topology.　A　relevant　mathematics　model　is　founded　with　its　objective　function　to　minimize　the　structural　weight　with　stress　constrain　considered.　In　the　order　to　solve　the　problem,　a　liner　programming　model　is　established　by　fully　stress　method　to　calculate　cables＇　pretension　force　and　cross　section　size　of　member.　Then　a　conclusion　is　proved　that　the　optimal　solution　of　the　liner　programming　model　makes　at　least　one　member　cross-section　size　zero　in　each　iteration,　and　topology　optimization　is　completed　by　deleting　the　member.　The　result　of　the　examples　in　this　paper　coincides　with　corresponding　structural　performance,　which　indicates　the　method　in　this　paper　is　effective　and　efficient,　and　can　provide　reasonable　layout　for　prestressed　cable-truss　structures.