An　expansive　polystyrene　granule　cement　(EPSC)　latticed　concrete　wall,　which　has　advantages　of　higher　loadbearing　and　better　environmental-friendly　construction,　has　been　widely　applied　in　reinforced　concrete　(RC)　frames　to　form　a　new　structural　system,　and　its　seismic　performance　has　become　a　hot　topic　in　the　field　of　earthquake　engineering.　This　paper　presents　the　experimental　and　numerical　studies　on　the　seismic　performance　of　RC　frames　with　EPSC　latticed　concrete　infill　walls.　A　full-scale　single-storey　model　structure　with　openings　in　the　walls,　various　spacings　of　steel　rebar　and　binding　methods　between　the　walls　and　the　RC　frame　was　designed,　and　then　tested　on　a　shaking　table　to　investigate　the　seismic　performance.　A　numerical　analysis　model　was　constructed　using　the　nonlinear　dynamic　modelling　software　ABAQUS.　The　comparative　analysis　of　the　test　data　and　simulation　results　indicate　that　the　designed　RC　frame　with　EPSC　latticed　concrete　infill　walls　has　satisfactory　seismic　performance,　including　the　good　collapse　resistance　and　energy　dissipation　capacity.　Especially　the　latticed　concrete　walls　can　significantly　strengthen　the　RC　frame　and　increase　its　lateral　stiffness,　and　the　model　structure　undergoes　a　super-major　earthquake　with　minor　inter-storey　rotational　displacements　(only　1/513).　Reduction　in　spacing　of　bars　can　delay　the　growth　of　cracks　in　the　walls　and　increase　the　ductility　of　the　structural　system.　Both　local　binding　method　and　through-rebar　binding　method　can　effectively　restrain　the　walls.　Compared　with　local　binding　method,　the　through-rebar　binding　method　can　play　an　effective　role　in　the　out-of-plane　stability　of　the　wall,　thus　improve　the　integrity　of　the　structural　system.　The　proposed　analytical　procedure　can　be　also　applied　in　simulating　the　seismic　performance　of　infilled　multi-storey　RC　frames.　To　achieve　more　comprehensive　assessment　the　performance　of　the　RC　frames　with　latticed　concrete　infill　walls,　further　study　on　its　global　and　local　ductility　relationships　and　the　failure　model　of　the　infilled　multi-storey　frame　should　be　carried　out.