In　this　research,　typical　vehicles　(cars　and　trucks)　were　chosen　for　real-vehicle　testing　with　a　random　sample　of　27　drivers.　Also,　pieces　of　equipment　were　employed　for　real-time　measurements　of　vehicle　speed　and　changing　indexes　of　physiology　and　psychology.　Through　analyzing　the　data　of　different　drivers　measured　on　various　combined　alignment,　the　orderliness　of　driver　workload　degree　was　obtained.　The　change　of　driver　workload　degree　induced　by　road　alignment　was　ahead　of　the　change　of　the　expressway　alignment,　which　implied　drivers＇　adaptation　characteristics,　cognition　and　judgment　in　response　to　the　changing　alignment.　In　addition,　authors　classified　the　standard　of　various　combined　alignment　section　on　expressway　according　to　the　orderliness.　Research　results　can　provide　reference　for　the　road　design　and　traffic　facility　layout　as　well　as　expressway　operation　and　management.