In　order　to　investigate　the　influence　of　non-stationary　characteristics　of　ground　motion　on　structural　response,　vibration　table　model　test　of　the　national　gymnasium　bi-directional　beam　string　structure　(plane　size　is　11.4　m　×　14.4　m)　is　performed　under　the　one-directional　and　multiple-directional　ground　motion　inputs　by　using　a　multiple　vibration　table　array　system,　and　the　3　groups　of　acceleration　time　histories　are　fitted　with　various　non-stationary　characteristics　of　intensity　and　frequency.　The　time-frequency　characteristics　of　the　ground　motions　are　obtained　through　analyzing　the　acceleration　records　in　the　NGA　database　of　USA.　The　results　show　that　the　structural　response　tends　to　be　enforced　along　with　steady-state　duration　of　the　ground　motion,　and　that　the　structural　response　will　be　enhanced　when　the　earthquake　energy　focuses.　There　is　a　direct　correlation　between　the　influence　of　non-stationary　characteristics　of　frequency　on　structural　response　and　the　change　of　the　frequency　with　time,　with　the　period　of　the　latter　part　being　significantly　longer　than　the　former　part,　significantly　enhancing　the　structural　response.　The　influences　of　the　intensities　and　frequencies　of　ground　motion　on　structural　response　are　consistent　under　various　constraints.