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Local resistances of nitrogen and helium across sudden expansion in small channels with diameters from 0.245 mm to 0.850 mm were experimentally investigated by using a pressure measurement method of the tiny gaps on the channels. The results showed that the local resistance coefficient was different for two kinds of gases. In laminar flow, the expansion coefficient for nitrogen and helium in microchannels is higher than that in conventional tubes, expansion coefficient of helium is higher than the nitrogen. In turbulent flow, the expansion resistance coefficient increases while Reynolds number increasing due to gas compressibility. In addition, the amplification of expansion coefficient is increasing with area ratio decrease.
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