Because　the　load　case　is　often　very　complicated　in　the　topology　optimization　of　continuum　structures,　there　is　a　phenomenon　of　the　load　sickness　that　likes　stiffness　sickness　in　the　structural　analysis.　The　reason　caused　the　load　sickness　is　that　most　algorithms　of　the　topology　optimization　have　not　considered　different　influences　between　the　loads　with　small　forces　and　the　loads　with　big　forces.　Therefore,　some　of　topology　paths　of　transferring　small　forces　may　disappear　during　iterative　process.　This　paper　dissects　the　phenomenon　of　the　load　sickness　and　classifies　the　phenomenon　into　three　cases:　1)　load　sickness　exists　between　load　cases,　but　not　within　each　load　case;　2)　load　sickness　exists　within　some　load　cases;　3)　load　sickness　exists　not　only　between　load　cases,　but　also　within　some　load　cases.　To　deal　with　problem　of　load　sickness,　a　strategy　based　on　strain　energy　is　put　forward,　using　ICM　method　with　stress　globalization,　the　problems　of　above　three　cases　of　load　sickness　are　solved　by　adopting　different　complementary　approaches　one　by　one.　For　topology　optimization　with　stress　constraints　under　multiple　load　cases,　the　stress　globalization　means　that　local　stress　constraints　are　transformed　into　global　energy　constraints　based　on　the　fourth　strength　criterion.　Several　numerical　examples　reveal　that　the　topology　paths　of　transferring　forces　can　be　obtained　more　easily　by　substituting　global　strain　energy　constraints　for　local　stresses　constraints,　and　the　problem　of　load　sickness　can　be　dealt　with　more　conveniently.