This　study　investigated　the　removal　of　antibiotics　by　sequencing-batch　membrane　bioreactor　(SMBR)　for　swine　wastewater　treatment.　Nine　compounds　categorized　into　three　groups　of　commonly　used　veterinary　antibiotics,　namely　sulfonamides,　tetracyclines　and　fluoroquinolones,　were　evaluated.　Results　showed　that　both　sulfonamides　and　tetracyclines　were　efficiently　removed　by　SMBR　(＞90%)　while　a　lower　removal　was　observed　for　fluoroquinolones　(＜70%).　Mass　balance　analysis　evidenced　that　biodegradation/biotransformation　was　the　main　mechanism　for　the　removal　of　antibiotics　in　SMBR　operation.　Moreover,　sludge　adsorption　and　membrane　retention　also　slightly　contributed　to　antibiotic　removal.　Of　the　three　groups　of　antibiotics,　tetracyclines　and　fluoroquinolones　were　more　prone　to　accumulate　in　biosolids.　It　is　noteworthy　that　antibiotics　temporarily　affected　SMBR　performance　by　inhibiting　sludge　growth　and　activity　as　well　as　increasing　the　concentrations　of　extracellular　polymeric　substances　and　soluble　microbial　products　in　the　mixed　liquor.　Nevertheless,　＞60%　of　organic　matter　and　nutrients　in　swine　wastewater　could　be　removed　over　SMBR　operation.　(C)　2019　Elsevier　B.V.　All　rights　reserved.