Holes　with　diameter　from　0.3-1　mm　need　to　be　processed　in　micro-sprinkler　irrigation　plastic　pipeline　for　agriculture.　This　requirement　cannot　be　satisfied　by　traditional　way　of　using　mechanical　punching.　Laser　drilling　in　such　pipeline　not　merely　brings　some　advantages　such　as　good　suitability　in　material,　high　efficiency　in　production　and　free　burr　on　porthole　but　also　improves　product　quality　and　increases　variety　of　product.　The　CW　fiber　laser　and　pulsed　fiber　laser　have　been　employed　on　drilling　in　micro-sprinkler　irrigation　plastic　pipeline　with　ingredient　of　PE　(Polyethylene)　in　the　experiment.　The　dependence　between　laser　power　and　hole　diameter　and　the　dependence　between　fluence　and　hole　diameter　have　been　achieved.　Finally,　holes　for　required　diameter　have　been　made　in　the　pipeline　by　using　CW　fiber　laser　and　pulsed　fiber　laser.