In　order　to　investigate　the　nonlinear　seismic　responses　of　isolated　bridges　with　lead　rubber　bearings　(LRB)　under　a　bi-directional　horizontal　earthquake　excitation,　a　bi-directional　coupled　elastic-plastic　model　of　LRB　under　two　horizontal　orthogonal　directional　excitations　was　established,　and　the　unidirectional　force-deformation　behavior　skeleton　curve　of　this　bi-directional　coupled　elastic-plastic　model　is　considered　to　be　bilinear.　Based　on　the　bi-directional　coupled　elastic-plastic　model　of　LRB,　an　analytical　model　of　nonlinear　seismic　responses　of　continuous　multi-span　isolated　bridges　with　LRB　and　its　solving　method　were　carried　out.　Finally,　the　comparison　of　the　calculation　results　of　nonlinear　earthquake　responses　obtained　by　considering　and　ignoring　the　bi-directional　coupled　interaction　of　bearing　restoring　force　is　made　for　one　example　of　the　isolated　bridges　with　LRB.　It　is　shown　that　the　bi-directional　coupled　interaction　of　the　restoring　forces　of　LRB　has　considerable　effects　on　the　seismic　responses　of　the　isolated　bridge.　If　these　couple　interaction　effects　are　ignored,　then　the　peak　bearing　displacements　are　underestimated,　which　can　be　crucial　for　the　design　of　isolated　bridges.