Based　on　the　10-mass　model,　the　earthquake　response　of　different　natural　period　isolation　structure　are　analyzed　by　using　the　equivalent　linear　method　and　time　history　analysis　method　according　to　the　China,　Japan　and　USA　code　in　the　paper.　It　is　found　that　the　response　spectrum　in　long　period　part　of　design　response　spectrum　of　China　code　is　too　large,　and　the　modified　equation　to　the　long　period　part　is　proposed　based　on　the　original　acceleration　response　spectrum.　In　the　end　of　the　paper,　aim　at　the　shaking　table　test　of　a　5-story　steel　isolation　structure,　the　earthquake　response　of　isolation　structure　is　compared　by　using　the　new　suggestion　modified　acceleration　response　equation　and　time　history　analysis　method,　and　the　results　obtained　with　the　modified　long　period　response　spectrum　is　consist　with　the　results　of　time　history　analysis　and　test.　The　response　analysis　results　by　using　the　suggestion　equation　of　response　spectrum　value　have　a　higher　analysis　precise　for　isolated　structures.