Permeate　flux　and　water　content　in　permeate　are　two　important　parameters　in　pervaporation.　Mathematical　model　for　continuous　cross-flow　ethanol-water　pervaporation　process　was　developed,　and　mathematical　simulation　of　the　given　operating　conditions　was　carried　out.　The　calculation　data　of　water　content　in　permeate　agreed　well　with　the　experimental　data.　These　contrast　can　be　used　to　optimize　the　operating　conditions.　In　addition,　the　regression　equations　of　permeate　flux　was　developed　to　optimize　the　operating　conditions.　These　equations　could　potentially　be　used　to　predict　permeate　flux　in　the　pervaporation　separation　of　water-ethanol　mixture.