The　low　cycle　fatigue　tests　with　tension-torsion　strain　controlling　were　performed　on　thin　tubular　specimens　of　GH4169　alloy　at　650°C.　The　tension-torsion　cyclic　stress-strain　response　and　plastic　behavior　under　different　load　path　were　studied　and　the　influences　of　load　path　and　equivalent　strain　value　on　fatigue　crack　propagation　were　analyzed.　The　results　showed　that　the　shapes　of　tension-compression　and　torsion　cyclic　stress-strain　hysteresis　loops　are　related　to　the　loading　waves　and　paths.　The　phase　difference　of　tension-torsion　loading　waves　causes　a　turn　of　the　stress-strain　hysteresis　loop　on　the　component　when　the　component　is　in　elasto-plastic　loading　stage　while　the　other　component　has　a　suddenly　load　change.　The　continuous　increment　of　plastic　strain　during　the　medial　and　last　cycle　stage,　which　combined　with　the　SEM　fractography　analysis,　was　considered　by　creep.　The　SEM　fractography　showed　that　the　load　paths　and　equivalent　strain　value　affected　the　fracture　surface　topographies.