In　this　paper,　prestressed　cable-truss　optimization　design　is　discussed　where　in　design　variables　including　cross-section　size,　cable　pretension　force　and　nodes　locations　of　member　and　cable,　the　constraint　conditions　of　a　two-stage　design　of　applying　prestress　and　applying　prestress　and　load　together　are　considered.　A　relevant　shape　optimization　mathematical　model　is　founded.　In　order　to　solve　the　problem,　the　design　variables　are　divided　into　two　subspaces:　the　first　one　is　the　cable　pretension　force　and　the　cross-section　size　optimization　space,　the　second　one　is　shape　optimization　space.　For　the　first　one,　a　new　solution　method　is　provided　to　reduce　the　structure　weight,　and　for　the　second　one,　evolutionary　method　of　nodes　is　applied　to　optimize　the　structural　shape　and　cable　locations　to　improve　the　structural　stiffness.　Examples　indicate　that　the　method　has　the　merit　that　the　structural　weight　reduces　gradually　without　decreasing　in　stiffness　and　the　structural　shape　works　up　to　the　optimal　status　in　the　optimization　design　of　prestressed　cable-truss　structures.