Based　on　destructive　the　result　of　destructive　load　of　a　10-year-old　pre-stressed　concrete　hollow　slab　and　on　the　load　distribution　and　the　single-load　model,　the　resistance-load　effect　analysis　and　calculation　are　discussed　separately　to　evaluate　the　reliability　and　safety　of　the　used　pre-stressed　concrete　hollow　slab.　The　analysis　result　indicates　that　the　single　slab　load　mode　decreases　the　reliability　and　safety　of　the　up-structure,　which　will　bring　problems　to　the　further　service　of　the　structure.　This　paper　will　provide　scientific　basis　for　structural　strengthening　of　in-service　pre-stressed　concrete　hollow　slabs.