The　shaking　table　tests　are　completed　on　a　steel　frame　model　with　aspect　ratio　of　5　with　horizontal　and　vertical　earthquake　input　of　different　earthquake　waves　in　this　paper,　and　the　numercial　analysis　of　earthquake　response　to　model　structure　is　also　performed　by　time　history　analysis　method.　The　experiment　results　show　that　the　large　aspect　ratio　isolated　structure　has　good　isolation　effect　under　the　earthquake　in　two　directions.　Under　the　action　of　strong　earthquake　waves,　we　found　that　the　isolation　layer　occured　tension　stress,　the　maximum　tension　stress　was　3.176　MPa,　however,　the　model　structure　did　not　overturn.　We　also　found　that　the　vertical　earthquake　input　had　small　influence　on　earthquake　response　to　isolated　structure　in　horizontal　direction.　It　is　proposed　that　the　influence　on　earthquake　response　to　vertical　earthquake　input　can　be　ignored　when　we　analyze　the　earthquake　response　in　horizontal　direction　for　a　isolated　structure　with　aspect　ratio　of　less　than　5.