The　manifold　micro-channel　(MMC)　heat　sink　has　such　advantages　as　low　thermal　resistance,　compact　structure,　small　amount　of　coolant,　low　flow　rate,　uniform　temperature　distribution　along　the　flow　direction,　but　high　pressure　drop　is　required　due　to　narrow　channel　width　and　increased　pump　power.　This　article　investigates　the　influence　of　surfactant　on　flow　characteristics　in　a　MMC.　An　anionic　surfactant　sodium　dodecyl　sulfate　(SDS,　95%　purity　grade)　100　mg·kg-1　aqueous　solution　and　a　new　type　of　green　non-ionic　surfactant　of　alkyl　polyglycoside　(APG,　98%　purity　grade)　300　mg·kg-1　aqueous　solution　were　used　separately　as　working　fluid.　The　results　demonstrated　that　drag　reduction　depended　on　flow　velocity　and　temperature.　In　laminar　flow　regime,　the　drag　reduction　effect　was　not　obvious;　but　when　the　fluid　entered　turbulent　flow　regime,　drag　reduction　was　enhanced　notably　and　especially　in　fully　developed　turbulent　flow　regions.　Furthermore,　temperature　rise　could　also　enhance　drag　reduction,　but　the　enhancement　of　drag　reduction　due　to　adding　SDS　was　less　than　APG.　By　comparing　the　drag　reduction　effect　of　SDS　and　APG　through　experiments,　it　was　concluded　that　APG　has　better　drag　reduction　effect　than　SDS　at　higher　temperatures.