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Author:

Shang, Z. (Shang, Z..) | Ren, X. (Ren, X..) | Zhang, J. (Zhang, J..) | Zhu, X. (Zhu, X..) | Qi, H. (Qi, H..) | Liu, Q. (Liu, Q..) | Zhang, K. (Zhang, K..) | Wu, S. (Wu, S..) | Zeng, Y. (Zeng, Y..)

Indexed by:

EI Scopus

Abstract:

Objective: As ultrasound has become an important therapeutic technique on tumor, in order to find the cell-killing effect of focused bi-frequency ultrasound activated hematoporphyrin derivatives, experimental study was processed in vitro. Methods: Tumor cells K562 and SW-480 were killed by focused bi-frequency ultrasound activated hematoporphyrin (Hp) derivatives under optimized ultrasonic parameters and the cell-killing effect was tested by MTT (Thiazolyl blue: 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H- tetrazolium bromide) technique. Results: The lower frequency (0.6 MHz) was better than the higher (1.1 MHz) in activating hematoporphyrin derivatives; the bi-frequency was better than monofrequency, and the cell-killing efficiency was 2-3 times of sum of the two kinds of ultrasounds which constitute bifrequency. Incubation for the 16 h was better than 4 h after the cells exposed to the ultrasound. Conclusion: The method of killing tumor cells by focused bi-frequency ultrasound activated hematoporphyrin derivatives is presented and evaluated in this paper. Copyright © 2006 ACPSEM/EA.

Keyword:

Tumors Ultrasonics Cells Porphyrins Chemotherapy

Author Community:

  • [ 1 ] [Shang, Z.]Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, China
  • [ 2 ] [Shang, Z.]Institute of Applied Acoustics, Shaanxi Normal University, Xi'an, Shaanxi, China
  • [ 3 ] [Ren, X.]Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, China
  • [ 4 ] [Zhang, J.]Institute of Applied Acoustics, Shaanxi Normal University, Xi'an, Shaanxi, China
  • [ 5 ] [Zhu, X.]Institute of Applied Acoustics, Shaanxi Normal University, Xi'an, Shaanxi, China
  • [ 6 ] [Qi, H.]College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi, China
  • [ 7 ] [Liu, Q.]College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi, China
  • [ 8 ] [Zhang, K.]College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi, China
  • [ 9 ] [Wu, S.]Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, China
  • [ 10 ] [Zeng, Y.]Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, China

Reprint Author's Address:

  • [zeng, y.]biomedical engineering center, beijing university of technology, beijing 100022, china

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Source :

Australasian Physical and Engineering Sciences in Medicine

ISSN: 0158-9938

Year: 2006

Issue: 3

Volume: 29

Page: 267-271

ESI Discipline: MOLECULAR BIOLOGY & GENETICS;

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 3

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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