Experimental study on in vitro tumor cell killing by focused bi-frequency ultrasound activated hematoporphyrin derivatives - 文章详情页

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EI Scopus

摘要：

Objective:　As　ultrasound　has　become　an　important　therapeutic　technique　on　tumor,　in　order　to　find　the　cell-killing　effect　of　focused　bi-frequency　ultrasound　activated　hematoporphyrin　derivatives,　experimental　study　was　processed　in　vitro.　Methods:　Tumor　cells　K562　and　SW-480　were　killed　by　focused　bi-frequency　ultrasound　activated　hematoporphyrin　(Hp)　derivatives　under　optimized　ultrasonic　parameters　and　the　cell-killing　effect　was　tested　by　MTT　(Thiazolyl　blue:　3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-　tetrazolium　bromide)　technique.　Results:　The　lower　frequency　(0.6　MHz)　was　better　than　the　higher　(1.1　MHz)　in　activating　hematoporphyrin　derivatives;　the　bi-frequency　was　better　than　monofrequency,　and　the　cell-killing　efficiency　was　2-3　times　of　sum　of　the　two　kinds　of　ultrasounds　which　constitute　bifrequency.　Incubation　for　the　16　h　was　better　than　4　h　after　the　cells　exposed　to　the　ultrasound.　Conclusion:　The　method　of　killing　tumor　cells　by　focused　bi-frequency　ultrasound　activated　hematoporphyrin　derivatives　is　presented　and　evaluated　in　this　paper.　Copyright　©　2006　ACPSEM/EA.

关键词：

Tumors Ultrasonics Cells Porphyrins Chemotherapy

作者机构：

[ 1 ] [Shang, Z.]Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, China
[ 2 ] [Shang, Z.]Institute of Applied Acoustics, Shaanxi Normal University, Xi'an, Shaanxi, China
[ 3 ] [Ren, X.]Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, China
[ 4 ] [Zhang, J.]Institute of Applied Acoustics, Shaanxi Normal University, Xi'an, Shaanxi, China
[ 5 ] [Zhu, X.]Institute of Applied Acoustics, Shaanxi Normal University, Xi'an, Shaanxi, China
[ 6 ] [Qi, H.]College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi, China
[ 7 ] [Liu, Q.]College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi, China
[ 8 ] [Zhang, K.]College of Life Science, Shaanxi Normal University, Xi'an, Shaanxi, China
[ 9 ] [Wu, S.]Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, China
[ 10 ] [Zeng, Y.]Biomedical Engineering Center, Beijing University of Technology, Beijing 100022, China

通讯作者信息：

[zeng, y.]biomedical engineering center, beijing university of technology, beijing 100022, china

电子邮件地址：

yjzeng@bjut.edu.cn

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