In　order　to　study　the　influence　of　the　ground　motion　spatial　effect　on　the　seismic　response　of　large　span　spatial　structures　with　isolation　bearings,　a　single-layer　cylindrical　latticed　shell　scale　model　with　a　similarity　ratio　of　1/10　was　constructed.　An　earthquake　simulation　shaking　table　test　on　the　response　under　multiple-support　excitations　was　performed　with　the　high-position　seismic　isolation　method　using　high　damping　rubber　(HDR)　bearings.　Small-amplitude　sinusoidal　waves　and　seismic　wave　records　with　various　spectral　characteristics　were　applied　to　the　model.　The　dynamic　characteristics　of　the　model　and　the　seismic　isolation　effect　on　it　were　analyzed　at　varying　apparent　wave　velocities,　namely　infinitely　great,　1000　m/s,　500　m/s　and　250　m/s.　Besides,　numerical　simulations　were　carried　out　by　Matlab　software.　According　to　the　comparison　results,　the　numerical　results　agreed　well　with　the　experimental　data.　Moreover,　the　results　showed　that　the　latticed　shell　roof　exhibited　a　translational　motion　as　a　rigid　body　after　the　installation　of　the　HDR　bearings　with　a　much　lower　natural　frequency,　higher　damping　ratio　and　only　1/2　similar　to　1/8　of　the　acceleration　response　peak　values.　Meanwhile,　the　structural　responses　and　the　bearing　deformations　at　the　output　end　of　the　seismic　waves　were　greatly　increased　under　multiple-support　excitations.