Qionghai　is　located　in　the　low　latitude　region　where　the　solar　altitude　angle　is　high.　It　is　a　typical　climate　with　high　temperature,　high　humidity,　intense　solar　radiation,　and　small　daily　temperature　variation.　Under　such　climate　conditions,　designing　optimal　wall　insulation　structures　is　critical　for　achieving　building　energy　saving.　This　paper　takes　a　hotel　building　as　a　case,　to　simulate　energy　consumption　of　the　building　with　different　wall　insulation　structures　in　Qionghai　by　EnergyPlus　software.　The　results　show　that　building　envelope　insulations　have　obvious　insulation　effect,　and　the　energy　saving　effect　of　external　insulation　and　sandwich　insulation　is　better　than　internal　insulation.　Internal　insulation　decreased　the　cold　load　index　of　10.34%,　while　external　insulation　and　sandwich　insulation,　respectively,　reduce　the　cold　load　index　of　12.21　and　12.34%.　The　energy　saving　effect　of　the　three　wall　insulation　structures　would　decrease　with　the　increase　of　autoclaved　lime-sand　brick　layer　thickness.　©　2020,　Springer　Nature　Singapore　Pte　Ltd.