Based　on　the　engineering　background　of　a　prefabricated　subway　station　in　China,　a　three-dimensional　numerical　model　of　soil-structure　interaction　was　established　on　the　basis　of　finite　element　software　ABAQUS.　A　concept　of　＇vertical　to　horizontal　ratio　(VHR)＇　for　seismic　influence　of　underground　structures　was　put　forward.　By　comparing　the　horizontal　and　vertical　seismic　time　history　analysis,　the　seismic　responses　of　assembled　structure　were　explored.　Vertical　seismic　effects　compared　to　horizontal　seismic　effects:　The　maximum　interlayer　displacement　difference　was　reduced　by　1.89mm　(VHR:　45.38%),　the　maximum　angle　of　the　vault　increased　0.008°　(VHR:　126.67%),　the　structural　shear　force　had　the　greatest　impact　(VHR:　112.02%),　the　second　bending　moment　(VHR:　102.12%),　the　minimum　axial　force　(VHR:　93.74%).　The　VHR　of　the　ground　center　caused　by　different　directions　of　seismic　wave　radiation　is　basically　the　same　as　the　PGA　ratio　of　seismic　wave　(2/3).　The　structure　was　relatively　sensitive　to　vertical　seismic,　had　excellent　resistance　to　deformation　and　mechanical　properties　as　a　whole.　©　2020　ISRM.