A　metal　organic　framework　(MOF)　based　adsorbent　of　type　UiO-66　was　hydrothermally　prepared　and　applied　to　simultaneous　sensing　and　removal　of　the　asthma　drug　clenbuterol.　TheMOF　possesses　a　large　specific　surface　area　(1460　cm2　center　dot　g-1)　and　a　stable　structure,　and　has　a　large　adsorption　capacity　for　clenbuterol　(160　mg　center　dot　g-1).　If　clenbuterol　binds　to　the　MOF,　the　fluorescence　of　the　sorbent　(best　measured　at　excitation/　emission　wavelengths　of　290/　396　nm)　is　quenched　by　up　to　88%.　Based　on　these　findings,　a　fluorometric　assay　has　been　developed　for　the　rapid　determination　of　clenbuterol.　The　adsorption　equilibrium　of　UiO-66　for　CLB　can　be　achieved　at　60　min　and　the　adsorption　efficiency　is　above　80%.　The　method　has　a　linear　response　in　the　4.0　to　40　ng　center　dot　mL-1　concentration　range,　and　the　lower　limit　of　detection　is　0.17　mu　M.　All　of　this　indicates　that　UiO-66　is　promising　for　simultaneous　detection　and　the　removal　of　CLB　in　water.