This　study　demonstrated　a　novel　process　configuration　for　sustaining　mainstream　anammox　by　integrating　the　anammox　and　endogenous　partial　denitrification-and-phosphorus　removal　(EPDPR)　in　two-stage　sequencing　batch　reactors　(SBRs).　In　the　EPDPR-SBR,　high　nitrate-to-nitrite　transformation　(68.2%)　and　P　removal　(99.3%)　were　achieved　by　adjusting　the　anaerobic/anoxic/aerobic　durations　and　influent　nitrate　concentration,　providing　a　suitable　NO2-　-N/NH4+-N　(similar　to　1.37)　for　subsequent　anammox　reaction.　In　the　Anammox-SBR,　similar　to　95%　of　TN　was　removed　without　external　carbon　and　oxygen　demands.　Satisfactory　effluent　quality　(similar　to　6　mgTN/L　and　0.2　mgP/L)　achieved　in　the　integrated　EPDPR/anammox　opens　a　new　window　towards　the　energy-efficient　wastewater　treatment.　Microbial　analysis　further　revealed　that　Dechloromonas　(1.6-9.6%)　and　Candidatus　Competibacter　(6.4-5.8%)　respectively　conducted　P　removal　and　NO2--N　production　(79.2%)　from　NO3--N　denitrification　in　the　EPDPR-SBR,　whereas　Candidatus　Kuenenia　(7.0-29.7%)　dominated　NO2--N　and　NH4+-N　removal　(91.3%　and　99.5%)　in　the　Anammox-SBR,　with　10　genera　identified　as　denitrifying　bacteria　(0.6-8.1%)　further　reduced　18.9%　of　the　produced　NO3--N.