A　series　of　numerical　simulation　were　performed　to　investigate　the　earthquake　response　of　a　bridge　under　multi-support　excitations　considering　site　effect.　Dynamic　behavior　of　the　bridge　including　the　key　position＇s　earthquake　reaction　and　acceleration　response　had　been　demonstrated,　respectively.　Results　show　that　the　complex　geological　site　had　a　great　influence　on　bridge＇s　seismic　response,　especially　on　the　superstructure.　The　research　results　could　provide　references　for　the　seismic　design　and　construction　of　bridge　structure.　©　2019　IOP　Publishing　Ltd.　All　rights　reserved.