The　hydrogel　is　a　kind　of　intelligent　soft　polymer　materials　exhibiting　obvious　chemo-mechanical　coupling　behavior　with　physical　properties　of　swelling　with　water　absorption,　and　dehydration　shrinkage.　For　the　mixed-mode　fracture　problem　in　the　hydrogel,　using　the　equivalent　domain　integral　method,　the　formulas　of　finite　element　numerical　calculation　of　Jk(k　=1,2)　integral　are　deduced　by　means　of　an　auxiliary　variable　and　a　reasonable　choice　of　two　characteristic　lengths　infinitely　close　to　the　crack　tip,　by　which　the　finite　element　program　of　Jk-integral　for　solving　fracture　parameters　is　developed.　The　correctness　of　the　program　is　verified　by　comparisons,　and　the　mixed-mode　fracture　problems　of　hydrogel　under　chemo-mechanical　coupling　are　numerically　studied,　which　confirms　the　domain　independence　of　mixed-mode　fracture　Jk-integral　under　chemo-mechanical　coupling.　The　developed　theoretical　model　and　numerical　program　in　this　work　will　provide　a　profound　insight　into　the　multi-field　coupling　and　fracture　mechanism　of　intelligent　hydrogel.　The　numerical　calculation　procedure　programmed　can　provide　an　effective　method　for　analyzing　the　design　and　optimization　of　intelligent　soft　devices　with　complex　geometries　and　structures.　©　2017　ICF　2017　-　14th　International　Conference　on　Fracture.　All　rights　reserved.