The　mesoporous　hybrid　silicas　(P@BMMs)　with　core-shell　structure　were　successfully　synthesized　via　seed　polymerization　method　using　bimodal　mesoporous　silica　materials　(BMMs)　as　core　and　dual　pH-　and　temperature-responsive　poly(N-isopropylacryl-acrylamide)-co-poly(acrylic　acid)　(P(NIPAM-co-AA))　copolymer　as　shell.　Meanwhile,　the　obtained　P@BMMs　were　physicochemically　and　morphologically　characterized　via　X-ray　diffraction,　N-2　adsorption-desorption　isotherms,　scanning　electron　microscopy,　transmission　electron　microscopy,　Fourier　transform　infrared,　ultraviolet　visible　diffused　reflection　spectrum,　small　angle　X-ray　scattering　(SAXS),　dynamic　light　scattering,　and　thermogravimetric　analysis　techniques.　The　results　indicated　that　P(NIPAM-co-AA)　was　successfully　coated　onto　the　mesoporous　surface　of　used　BMMs,　while　the　uniform　mesoporous　structure　of　obtained　P@BMMs　was　still　preserved.　Using　ibuprofen　(IBU)　as　a　model　drug,　the　influence　of　the　P(NIPAM-co-AA)　shell　on　the　release　kinetics　of　IBU　was　explored,　and　its　performances　elucidated　that　the　P@BMMs　nanoparticles　presented　an　apparent　thermo/pH-responsive　properties,　which　could　be　regulated　via　adjusting　mass　ratio　of　AA　to　NIPAM,　and　their　IBU-release　kinetic　profiles　were　favorable　to　Korsmeyer-Peppas　model.　Specially,　SAXS　patterns　were　employed　to　evaluate　the　fractal　evolution　of　P@BMMs　along　with　releasing　time,　showing　the　decline　tendency　for　mass　fractal　value　from　2.89　to　2.56　during　the　release　time　of　0.25-24　h.　[GRAPHICS]　.