Steam　ejector　as　an　energy-saving　unit　is　of　critical　importance　to　the　overall　performance　of　MED-TVC　desalination　system.　In　this　study,　a　combined　pressure　regulation　solution　is　proposed　to　dredge　the　blocked　entrained　flow　and　alleviate　the　high-pressure　effect　simultaneously　for　multiple　optimization　of　the　entrainment　passage　flow　field.　The　systematic　analysis　and　investigation　mainly　concentrate　on　the　feasibility　verifications　of　the　combined　pressure　regulations,　and　the　performance　comparisons　between　the　combined　and　single　pressure　regulation　schemes　under　various　operating　conditions.　The　results　reveal　that　the　throat-combined　pressure　regulation　would　simply　lose　efficacy,　the　diffuser-　and　multi-combined　pressure　regulations　could　achieve　a　similar　multiple　optimization　that　the　alleviation　effectiveness　remains　almost　steady　and　the　dredging　effectiveness　enhances　continually　as　the　back　pressure　decreases.　Moreover,　there　is　an　optimum　combination　among　the　pressure　regulation　schemes,　by　which　a　most　significant　entrainment　ratio　improvement　could　be　achieved,　as　high　as　28.75%　in　the　present　simulations　covered　range.　To　be　specific,　TMCE　pressure　regulation　could　be　selected　if　the　ejector　operates　under　the　design　condition,　and　for　the　off-design　conditions,　multi-combined　pressure　regulation　should　be　adopted　if　the　back　pressure　not　exceeds　its　critical　value,　otherwise,　CMCE　pressure　regulation　is　the　best　choice.　(C)　2019　Elsevier　Ltd.　All　rights　reserved.