In　natural　water,　natural　organic　matter　(NOM)　components　have　been　identified　as　precursors　of　disinfection　byproducts.　Nanofiltration　has　been　widely　recognized　as　a　promising　technology　to　remove　NOM　from　natural　water.　Currently,　the　most　challenging　aspect　is　the　often　inevitable　occurrence　of　membrane　fouling,　which　is　caused　by　NOM　accumulation　on　the　membrane　surface,　as　in　NOM　removal　in　drinking　water　treatment　and　production.　NOM　fouling　is　considered　to　be　governed　by　the　interface　relationship　between　NOM　and　the　membrane　surface　in　aqueous　solution.　Much　work　has　been　carried　out,　but　the　effect　of　hydrophilicity/-phobicity　of　NOM　and　the　membrane　surface　on　fouling　behavior　is　still　a　controversial　issue.[1-7]　The　controversy　originates　from　the　unilateral　consideration　of　membrane　wettability　or　foulant　hydrophilicity/-phobicity,　when　in　fact　both　need　to　be　considered.　In　our　study,　both　superhydrophilic　and　superhydrophobic　membranes　with　stable　structure　have　been　successfully　obtained　using　two　facile　hybrid　approaches　(see　Fig.　1).　The　fouling　behavior　of　NOM　on　superwetting　nanofiltration　membranes　has　been　extensively　investigated　using　humic　acid　(HA:　model　foulant)　and　real　natural　water.　The　extended　Derjaguin-Landau-Verwey-Overbeek　(XDLVO)　approach　and　nanoindentor　scratch　tests　suggested　that　the　superhydrophilic　membrane　had　the　strongest　repulsion　force　to　HA　due　to　the　highest　positive　GTOT　value　and　the　lowest　critical　load.　Excitation　emission　matrix　analyses　of　natural　water　also　indicated　that　the　superhydrophilic　membrane　showed　resistance　to　fouling　by　hydrophobic　substances　and　therefore　high　removal　thereof.　Conversely,　the　superhydrophobic　membrane　showed　resistance　to　fouling　by　hydrophilic　substances　and　therefore　high　removal　thereof　(see　Figs.　2　and　3).　Long-term　operation　suggested　that　the　superhydrophilic　membrane　had　high　stability　due　to　its　anti-NOM　fouling　capacity,　which　is　crucial　for　practical　application.　Based　on　the　different　anti-fouling　properties　of　the　studied　superwetting　membranes,　a　combination　of　superhydrophilic　and　superhydrophobic　membranes　was　examined　to　further　improve　the　removal　of　both　hydrophobic　and　hydrophilic　pollutants.　The　RUV254　and　RDOC　could　be　increased　to　83.6%　and　73.3%,　respectively,　by　a　combination　of　superhydrophilic　and　superhydrophobic　membranes.　In　view　of　the　hydrophilic　and　hydrophobic　NOM　fouling　behaviors　on　superwetting　membrane　surfaces,　the　superwetting　strategy　can　be　regarded　as　a　very　important　approach　for　obtaining　a　membrane　with　both　high　NOM　rejection　and　good　anti-NOM　fouling　properties.