Abnormal　metabolism　of　tumour　cells　is　closely　related　to　the　occurrence　and　development　of　breast　cancer,　during　which　the　expression　of　NF-E2-related　factor　2　(Nrf2)　is　of　great　significance.　Metastatic　breast　cancer　is　one　of　the　most　common　causes　of　cancer　death　worldwide;　however,　the　molecular　mechanism　underlying　breast　cancer　metastasis　remains　unknown.　In　this　study,　we　found　that　the　overexpression　of　Nrf2　promoted　proliferation　and　migration　of　breast　cancers　cells.　Inhibition　of　Nrf2　and　overexpression　of　Kelch-like　ECH-associated　protein　1　(Keap1)　reduced　the　expression　of　glucose-6-phosphate　dehydrogenase　(G6PD)　and　transketolase　of　pentose　phosphate　pathway,　and　overexpression　of　Nrf2　and　knockdown　of　Keap1　had　opposite　effects.　Our　results　further　showed　that　the　overexpression　of　Nrf2　promoted　the　expression　of　G6PD　and　Hypoxia-inducing　factor　1　alpha　(HIF-1　alpha)　in　MCF-7　and　MDA-MB-231　cells.　Overexpression　of　Nrf2　up-regulated　the　expression　of　Notch1　via　G6PD/HIF-1　alpha　pathway.　Notch　signalling　pathway　affected　the　proliferation　of　breast　cancer　by　affecting　its　downstream　gene　HES-1,　and　regulated　the　migration　of　breast　cancer　cells　by　affecting　the　expression　of　EMT　pathway.　The　results　suggest　that　Nrf2　is　a　potential　molecular　target　for　the　treatment　of　breast　cancer　and　targeting　Notch1　signalling　pathway　may　provide　a　promising　strategy　for　the　treatment　of　Nrf2-driven　breast　cancer　metastasis.