Based　on　the　isothermal　fatigue　and　creep　damage,　a　life　prediction　approach　under　multiaxial　thermo-mechanical　loading　was　proposed　in　this　investigation.　In　the　proposed　method,　the　multiaxial　thermo-mechanical　fatigue　damage　during　one　cycle　period　was　divided　into　the　isothermal　fatigue　damage　and　the　creep　damage.　In　order　to　evaluate　conservatively,　the　isothermal　fatigue　damage　during　one　cycle　period　was　calculated　by　using　multiaxial　fatigue　damage　model　at　the　maximum　temperature　during　the　whole　period,　and　the　creep　damage　during　one　cycle　period　was　calculated　by　accumulating　the　creep　damage　of　all　portions　originated　from　the　divided　time　history　for　the　axial　load　component　and　temperature　history.　The　life　prediction　results　by　the　proposed　model　showed　a　good　agreement　with　experimental　data　for　nickel-base　alloy　GH4169　and　cobalt-base　Haynes188　under　axial-torsional　thermo-mechanical　loading.