In　the　face　of　increasingly　market　competition　and　diversified　demand,　manufacturers　and　dealers　of　Manufacturing　Supply　Chain　(MSC)　pay　great　effort　to　achieve　production　marketing　coordination.　However,　it　often　generates　conflicts　in　the　process　of　production　marketing　coordination.　For　this　kind　of　conflict　problem,　Multi-Agent　technology　is　introduced.　Enterprises　of　the　supply　chain　are　represented　by　Agents.　The　conflicts　among　Agents　are　resolved　through　Nash　negotiation.　A　model　of　Nash　Negotiation　based　on　Agents　is　established.　The　conflict　point　of　negotiation　is　determined　by　Stackelberg　differential　game.　A　Memetic　Algorithm　is　proposed　to　solve　the　model.　Finally,　the　validity　of　the　algorithm　and　the　model　is　verified　by　numerical　experiment.　©　IFIP　International　Federation　for　Information　Processing　2014.