Steel-concrete　composite　frame　is　one　of　the　widely　used　structural　systems.　Earthquake　and　progressive　collapse　due　to　accidental　localized　damage　are　the　main　hazards　that　affect　the　safety　of　steel-concrete　composite　frames.　Therefore,　a　seismic　and　progressive　collapse　resistant　composite　frame　(SPCRCF)　structural　system　is　proposed　based　on　a　comprehensive　consideration　of　the　seismic　and　progressive　collapse　design　requirements.　The　seismic　and　progressive　collapse　performances　of　the　proposed　SPCRCF　were　compared　with　the　conventional　steel-concrete　composite　frame　using　the　experimental　results　of　four　specimens.　The　general-purpose　finite　element　software,　MSC.Marc,　was　used　to　simulate　the　specimens.　The　experimental　and　simulation　results　show　that　the　proposed　SPCRCF　has　better　seismic　resilience　(low　damage,　self-centering,　and　easy　repair)　and　larger　progressive　collapse　resistance　compared　to　conventionally　designed　steel-concrete　composite　frames.