A　method　which　can　personalize　the　lumped　parameter　model　of　coronary　artery　and　cardiovascular　system　based　on　the　non-invasive　physiological　parameters　has　been　developed.　The　parameters　of　system　were　determined　by　different　physiological　parameters.　The　heart　module　was　determined　by　aortic　pressure　and　heart　rate;　the　systemic　circulation　module　was　determined　by　cardiac　output,　height　and　cardio-ankle　vascular　index　(CAVI),　while　the　CAVI　was　determined　by　age　and　aortic　pressure;　the　coronary　module　was　determined　by　the　target　waveforms　of　coronary　flow　rate　predicted　from　cardiac　output.　The　considerable　results　proved　that　this　method　could　be　applied　to　each　patient.