To　improve　the　calculation　efficiency　and　accuracy　of　numerical　simulation　of　structure　seismic　damage,　multi-scale　finite　element　modeling　is　introduced　in　this　paper.　Two　different　treatment　schemes　of　interface　coupling　between　different-scale　models　by　using　a　force　equilibrium　condition　and　a　deformation　compatibility　condition　were　researched.　Finally,　a　bridge　that　collapsed　in　the　Wenchuan　earthquake　is　used　as　an　example　to　illustrate　the　suggested　approach　in　this　paper.　A　multi-scale　finite　element　model　of　a　bridge　was　established　based　on　ABAQUS　software.　The　seismic　damage　and　the　collapse　process　were　simulated　and　compared　with　the　actual　seismic　damage　investigation　to　verify　the　validity　of　multi-scale　finite　element　modeling.　The　research　indicates　that　multi-scale　finite　element　model　can　be　applied　to　reasonably　and　effectively　simulate　the　local　damage　and　whole　collapse　of　a　complex　bridge　due　to　an　earthquake,　and　the　treatment　scheme　by　using　a　force　equilibrium　condition　can　meet　the　stress　and　deformation　compatibility　well　at　the　interface　between　different-scale　models.　©　2014　American　Society　of　Civil　Engineers.