The　tool　magazine　and　automatic　tool　changer　are　important　functional　components,　which　actual　performance　affects　the　efficiency　of　machining　center　directly.　BT50-32L　produced　by　ZhongHuan(Group)　is　the　research　object　in　this　paper,　it　introduces　the　application　of　the　control　system　from　aspects　of　the　design　of　overall　program,　the　control　of　tool　magazine　and　automatic　tool　changer.　The　core　of　the　tool　magazine　control　system　is　PLC,　which　can　select　the　nearest　tool　and　achieve　the　control　of　tool　position,　the　flip　of　tool　holder　and　the　tool　changer　of　manipulator　during　the　operation.　The　communication　of　PC　HMI　and　PLC　achieve　the　simulation　and　control　of　the　operational　status.　This　system　is　certified　to　meet　the　application　requirements　with　the　stable　performance,　simple　structure,　easy　operation　and　the　rapid　and　accurate　action.　©　(2014)　Trans　Tech　Publications,　Switzerland.