In　this　challenge,　we　intended　to　mimic　the　patient＇s　cardiovascular　system　by　using　0D-3D　connected　multiscale　model.　The　purpose　of　the　multiscale　analysis　is　to　find　out　the　appropriate　boundary　conditions　of　the　innominate　artery　(IA),　left　common　carotid　artery　(LCA)　and　left　subclavian　artery　(LSA)　in　the　local　3D　computational　fluid　dynamics　simulation.　Firstly,　a　lumped　parameter　model(LPM)　of　the　patient＇s　circulatory　system　was　established　which　could　mimic　both　the　rest　and　stress　conditions　by　adjusting　parameters　like　elastance　function　of　the　heart　and　the　peripheral　resistance,　since　that　administering　is　oprenaline　leads　to　the　patient＇s　heart　beat　rate　and　peripheral　resistance　changes.　Secondly,　the　values　of　parameters　in　the　LPM　were　slightly　revised　to　match　the　following　conditions:　1.　provided　pressure　and　flow　rate　curves,　2.　provided　blood　distribution　ratio　of　the　AcsAo,　IA,　LCA　and　LSA.　Finally,　we　got　the　outlet　conditions　of　the　IA,　LCA　and　LSA,　and　then　connecting　the　0D　model　and　the　3D　model　at　each　time　step.　As　the　results,　we　got　the　streamlines,　pressure　drop　through　the　coarctation,　pressure　gradient,　and　some　other　parameters　by　coupled　multiscale　simuation.　©　Springer-Verlag　Berlin　Heidelberg　2014.