Nanomaterial-based　tumor　photothermal　therapy　(PTT)　has　attracted　increasing　attention　and　been　a　promising　method　for　cancer　treatment　because　of　its　low　level　of　adverse　effects　and　noninvasiveness.　However,　thermotherapy　alone　still　cannot　control　tumor　metastasis　and　recurrence.　Here,　we　developed　surface-functionalized　modified　copper　sulfide　nanoparticles　(CuS　NPs).　CuS　NPs　can　not　only　be　used　as　photothermal　mediators　for　tumor　hyperthermia　but　can　adsorb　tumor　antigens　released　during　hyperthermia　as　an　antigen-capturing　agent　to　induce　antitumor　immune　response.　We　selected　maleimide　polyethylene　glycol-modified　CuS　NPs　(CuS　NPs-PEG-Mal)　with　stronger　antigen　adsorption　capacity,　in　combination　with　an　immune　checkpoint　blocker　(anti-PD-L1)　to　evaluate　the　effect　of　hyperthermia,　improving　immunotherapy　in　a　4T1　breast　cancer　tumor　model.　The　results　showed　that　hyperthermia　based　on　CuS　NPs-PEG-Mal　distinctly　increased　the　levels　of　inflammatory　cytokines　in　the　serum,　leading　to　a　tumor　immunogenic　microenvironment.　In　cooperation　with　anti-PD-L1,　PTT　mediated　by　CuS　NPs-PEG-Mal　enhanced　the　number　of　tumor-infiltrating　CDR+　T　cells　and　inhibited　the　growth　in　primary　and　distant　tumor　sites　of　the　4T1　tumor　model.　The　therapeutic　strategies　provide　a　simple　and　effective　treatment　option　for　metastatic　and　recurrent　tumors.