Background:　Exposure　to　cadmium　(Cd)　is　a　major　environmental　pollutant　that　causes　injury　on　many　organs　and　tissues,　particularly　the　liver.　However,　the　protection　of　radish　seed　aqueous　extract　(RSE)　against　hepatic　injury　in　Cd-exposed　mice　yet　remains　unclear.　Objective:　The　research　aimed　to　investigate　the　mitigation　effect　of　RSE　against　Cd-induced　hepatotoxicity　in　experimental　animals.　Materials　and　Methods:　The　mice　were　administered　intraperitoneally　with　Cd　Chloride　(CdCl2,　75　mg/kg　b.　wt)　as　a　positive　control　to　compare　RSE.　The　hepatic　function　and　antioxidant　status　were　assessed　in　liver　tissue　of　poisoned　and　control　mice.　Results:　Levels　of　serum　hepatic　enzymes　(aspartate　transaminase:　AST　and　alanine　transaminase:　ALT)　as　well　as　total　bilirubin　were　significantly　increased　in　Cd-exposed　mice.　In　addition,　Cd　exposure　elicited　enhancement　of　oxidative　stress　level.　Co-treatment　with　RSE　(200　and　400　mg/kg　b.　wt)　significantly　decreased　the　serum　levels　of　liver　function　biomarkers.　Furthermore,　RSE　treatment　showed　a　significant　reduction　of　lipid　peroxidation　and　increase　of　enzyme　and　glutathione　concentrations.　Histopathological　analysis　was　parallel　to　these　biochemical　findings.　Conclusion:　The　results　clearly　demonstrated　that　RSE　is　effective　for　ameliorating　hepatic　cytotoxicity　and　oxidative　damage　arising　from　Cd　exposure.