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作者:

Zhang, Yuan (Zhang, Yuan.) | Ge, Liang (Ge, Liang.) | Du, Nan (Du, Nan.) | Fan, Guoqiang (Fan, Guoqiang.) | Jia, Kebin (Jia, Kebin.) (学者:贾克斌) | Zhang, Aidong (Zhang, Aidong.)

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EI Scopus

摘要:

Many works have been done to identify functional modules in Protein-Protein Interaction (PPI) networks but the results are far from satisfaction. One main reason is that the PPI data generated from high-throughput experiments is noisy and incomplete. Solving the problem goes beyond what a single data source can provide and thus requires the integration of multiple information sources. To address this problem, we hereby propose a graph-based cluster ensemble method which integrates gene ontology (GO) and gene expression data with PPI networks. Experimental results show that our method is superior to the baseline methods and demonstrate the benefits of integrating multiple biological information sources and diverse clustering methods.

关键词:

Algorithms Bioinformatics Gene expression Graphic methods Proteins

作者机构:

  • [ 1 ] [Zhang, Yuan]Beijing University of Technology, Beijing, 100124, China
  • [ 2 ] [Ge, Liang]State University of New York at Buffalo, Buffalo, 14260, United States
  • [ 3 ] [Du, Nan]State University of New York at Buffalo, Buffalo, 14260, United States
  • [ 4 ] [Fan, Guoqiang]Beijing University of Technology, Beijing, 100124, China
  • [ 5 ] [Jia, Kebin]Beijing University of Technology, Beijing, 100124, China
  • [ 6 ] [Zhang, Aidong]State University of New York at Buffalo, Buffalo, 14260, United States

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年份: 2012

页码: 567-569

语种: 英文

被引次数:

WoS核心集被引频次: 0

SCOPUS被引频次: 2

ESI高被引论文在榜: 0 展开所有

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