Conformal　treatment　for　microwave　ablation　has　been　the　research　aim　in　the　hyperthermia　field.　In　this　paper,　a　patient-specific　temperature-based　optimization　algorithm　is　proposed,　which　can　be　applied　to　explore　optimum　thermal　filed　model　covering　entire　tumor　and　minimizing　the　damage　to　healthy　tissues.　50　optimization　experiments　were　performed　and　the　results　indicated　the　algorithm　mentioned　above　is　fast　and　effective　in　the　practice.　Applying　the　algorithm,　it　may　help　physicians　to　establish　optimum　treatment　scheme　before　hepatic　tumor　microwave　ablation.　©　2012　IEEE.