With　the　expansion　of　collaboration　in　supply　chain,　the　design　and　operation　of　the　supply　chain　should　be　considered　as　a　whole　system,　in　which　the　decision　making　and　operation　of　enterprises　are　no　longer　independent.　Local　and　dyadic　relationship　considerations　were　not　enough.　It　is　necessary　to　treat　the　supply　chain　as　a　complex　network,　from　the　overall　perspective　using　a　holistic　network　model　to　study　the　structure,　operation　and　flow　transmission　of　the　whole　supply　chain　vertically　or　all　entities　in　a　certain　node　of　supply　chain　horizontally.　Using　systems　engineering　we　established　a　common　indicative　framework　of　holistic　network　multi-agent　simulation　model,　it　can　well　describe　a　wide　collaborated　dynamic　supply　network,　provide　a　good　reference　to　decision　support,　comprehensive　assessment　and　prediction　for　strategic　layer　and　operational　layer　of　entire　supply　network.　And　the　analysis　in　this　paper　provides　a　basis　for　future　research　and　a　framework.　©　2011　IEEE.