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In this study, the fabrication of microfluidic chip ontaining a row of 198 micropillars was described. The geometric deformation of micropillars in icrofluidic chip on the PI and PMMA substrates was aused by cumulative heat during laser ablation. nalysis of the cumulative heat effect of PI polyimide) and PMMA was done (polymethyl ethacrylate) when ablated using a KrF excimer laser or microfluidic. We researched the variation of icropillars' geometric deformation on the different luence and the number of laser pulses according to xperimental observations. The number of laser pulses enerates a greater geometric deformation in PMMA than in PI. The diameter of the top of micropillars increase is attributed to a smaller thermal expansion coefficient of PI that enables a smaller melted volume o form. In connection with PI, The relation between the laser pulses and the top and bottom diameter of the icropillars has been got. The cause has been analyzed.
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