In　order　to　ensure　traffic　safety　operation　under　limited　visibility　conditions,　this　paper　provide　an　innovative　solution　-　Intelligent　Guidance　System　for　Foggy　Area　Traffic　Safety　Operation.　This　Intelligent　guidance　system　mainly　consists　of　visibility　tester,　illuminant　guidance　facilities,　traffic　flow　detectors,　variable　message　signs,　local　and　superior　controller.　According　to　different　visibilities　and　flow　conditions,　system　controller　can　adjust　brightness,　color,　flashing　frequency,　etc.　of　the　illuminant　guidance　facilities　to　implement　guidance　strategy.　The　system　can　provide　roadway　outline　reinforcement,　vehicle　active　guidance,　rear-end　collision　warning　and　safety　information　advice　functions.　The　biggest　advantage　of　the　system　is　the　rear-end　collision　warning　function,　which　dynamically　generate　red　warning　belt　to　indicate　the　following　space,　thus,　to　ensure　vehicles　to　pass　foggy　road　section　safely　to　great　extent.　Constitution　of　system,　principle　of　operation,　and　control　strategy　of　system　are　elaborated　in　this　paper.　©　2011　IEEE.