Based　on　the　time-temperature　parameter　method,　a　modified　von　Mises　stress　is　proposed　to　calculate　the　multiaxial　creep　damage　at　high　temperature.　By　employing　the　strain-based　multiaxial　fatigue　damage　models,　the　modified　von　Mises　stress　is　used　to　predict　the　creep-fatigue　life　under　variable　amplitude　multiaxial　loading　at　high　temperature.　The　experimental　data　of　GH4169　superalloy　and　304　stainless　steel　conducted　under　both　constant　and　variable　amplitude　loadings　at　high　temperature　are　used　to　verify　the　proposed　method,　and　a　good　agreement　is　obtained　with　the　experimental　data.