Traffic　safety　on　low　traffic　volume　highway　is　one　of　the　hidden　threats　against　road　traffic　safety　and　the　characteristic　of　driver　factor　is　an　important　factor　which　cannot　be　neglected　among　various　accident　causes　in　China.　The　present　study　conducts　a　test　on　driver　factor　of　25　drivers.　It　chooses　the　Geermu-Kunlun　Mountain　Entrance　road　section　of　the　low　traffic　volume　Qinghai-Tibet　Highway　as　its　trial　section.　The　instruments　concluding　dynamic　GPS,　dynamic　electrocardiogram　and　eye　tracker　are　proposed　as　real-time　measurement　of　subject　drivers＇　driving　speed,　vision　point,　driving　workload,　and　other　parameters　and　indexes.　This　study　analyzes　the　human　factor　which　vehicle　running　speed　and　track　characteristics　of　driving　behavior,　eye　movement　and　driver　behavior　of　driver　characteristics　based　on　the　dynamic　interaction　among　driver,　vehicle,　road,　and　environment.　Compared　with　traffic　accident　on　low　traffic　volume　highway　in　plateau　area,　experimental　research　conclusion　indicates　that　driver　factor　is　the　key　factor　of　traffic　accident.　The　conclusions　provide　an　important　reference　for　traffic　safety　technology　and　management　on　low　traffic　volume　highway　in　plateau　area.　©　2010　IEEE.